News | Genome Sciences Centre

GSC researchers develop new method of single-cell RNA sequencing

A new method of single-cell RNA sequencing allows for high-throughput, full-length, strand-specific sequencing of transcripts.

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Tumor sequencing panel screens for both somatic and germline changes of clinical significance

The GSC has developed a next-generation sequencing test that can identify both acquired and inherited gene changes in tumor tissue. A paper published in the Journal of Molecular Diagnostics explains how this information can be used in the clinical management of patients with advanced cancers and their families.

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A novel transcriptome-based clinical assay allows for improved risk group stratification of acute myeloid leukemia patients

In a new study published in Nature Communications, GSC researchers used the power of next generation sequencing technologies to develop a clinical test that improves acute myeloid leukemia patient stratification.

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Dr. Marco Marra joins Canada’s Medical Hall of Fame

Today, six outstanding individuals were inducted into the Canadian Medical Hall of Fame. Among them, Dr. Marco Marra, Director of Canada’s Michael Smith Genome Sciences Centre at BC Cancer. Visit the Canadian Medical Hall of Fame website to view the 2020 Induction Ceremony

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A new method for analyzing silenced genes

Cancers are diseases of the genome. They can result from minor changes to single or a few base pairs, known as mutations, or from larger structural changes to the genome, including how it is packaged into chromosomes and manipulated by other molecules. Understanding how things have gone wrong in specific cancers can help scientists develop better prognostic tools and treatment strategies.

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Pediatric case study demonstrates value in whole genome sequencing for cancer treatment planning

Whole genome sequencing allows for the identification of novel genomic alterations that are not detected by standard clinical techniques. In some cases, identification of these features can reveal therapeutic options for patients with otherwise untreatable cancers.

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New study provides insight into the molecular biology of colorectal cancer

In a new study published in the journal Cancer Biology & Therapy, Dr. Tai’s research group characterized the involvement of a multi-functional protein, called NPM1, in colorectal cancer growth and treatment resistance, providing the research community with a potential therapeutic target for the treatment of the disease.

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World Cancer Day 2021

February 4 is World Cancer Day—a global initiative led by the Union for International Cancer Control. Patients, families, communities, clinicians, researchers and others are joining together to raise awareness and to act.

Here at Canada’s Michael Smith Genome Sciences Centre at BC Cancer, we are making significant strides in realizing the benefit of genomics in researching, understanding, diagnosing and treating cancer.

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Parkinson’s disease and lung cancer: LRRK2 gene a shared culprit?

LRRK2 is a highly studied gene in Parkinson’s disease, where increased activity is thought to play a causative role. Now, new research has established that decreased LRRK2 expression can be involved in the development of lung adenocarcinoma.

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