EXPRESSION ANALYSIS
This section provides details of the expression analyses performed as part of the POG pipeline. Look in this section for details about expression comparator choice and potentially relevance genes determined to be significant expression outliers.
EXPRESSION ANALYSIS
SPEARNMAN CORRELATION WITH AVAILABLE EXPRESSION DATASETS
Normal Expression Comparator
Disease Expression Comparator
compendium average
SARC
EXPRESION LEVEL OUTLIERS OF POTENTIAL CLINICAL RELEVANCE
Gene Location Copy Change LOH State CNV State Expression (RPKM) Fold Change
vs. average
SARC
%ile
CCNA2 4:122737599-122745087 0 HET Neutral 28.38 8.13 93
CES2 16:66968347-66978999 0 NLOH Neutral 29.43 2.25 100
MYC 8:128747680-128753674 +2 ALOH Gain 60.13 2.67 86
PTEN 10:89622870-89731687 0 HET Neutral 7.02 -2.38 10
SKP2 5:36152091-36184421 0 HET Neutral 11.29 3.27 93
EXPRESION LEVEL OUTLIERS OF PROGNOSTIC AND DIAGNOSTIC RELEVANCE
Gene Location Copy Change LOH State CNV State Expression (RPKM) Fold Change
vs. average
SARC
%ile
CES2 16:66968347-66978999 0 NLOH Neutral 29.43 2.25 100
EXPRESION LEVEL OUTLIERS OF BIOLOGICAL RELEVANCE
Gene Location Copy Change LOH State CNV State Expression (RPKM) Fold Change
vs. average
SARC
%ile
CCNA2 4:122737599-122745087 0 HET Neutral 28.38 8.13 93
CES2 16:66968347-66978999 0 NLOH Neutral 29.43 2.25 100
MYC 8:128747680-128753674 +2 ALOH Gain 60.13 2.67 86
PTEN 10:89622870-89731687 0 HET Neutral 7.02 -2.38 10
SKP2 5:36152091-36184421 0 HET Neutral 11.29 3.27 93
TOP2A 17:38544768-38574202 0 HET Neutral 132.57 30.1 98
TP53 17:7565097-7590856 0 HET Neutral 49.13 3.85 98
EXPRESION DISTRIBUTIONS